Below you will find information about ongoing clinical trials being conducted by EPC members
Contents |
PMAPS - Pancreatitis – Microbiome As Predictor of Severity
A prospective multicentre translational study
This trial is registered on clinicaltrials.gov: NCT04777812
PI: Albrecht Neesse, MD, PhD
Gastroenterology, Gastrointestinal Oncology and Endocrinology
University Medical Centre Göttingen, Germany
Study details
Hypothesis: The orointestinal microbiome may be utilized as early biomarkers for the severity and course of AP
Enrollment:
- Inclusion criteria: Patients with acute pancreatitis, hospital stay < 72h
- Exclusion criteria: Pregnancy, age <18 years
- Primary endpoint: Association of revised Atlanta classification with microbiome patterns
- Secondary endpoints: Length of hospital stay, mortality, number of interventions
Clinical samples:
- Microbiome of buccal and rectal swabs (non-invasive)
- Clinical data will be collected with a standardized online questionnaire
- Swab tubes will be provided, shipment costs will be paid
- Translated study protocol, patient consent forms and ethical approvals for EU-Hospitals available
Sequencing platform in Göttingen, Germany:
- DNA extraction with established protocols conform with International Human Microbiome Standards (IHMS)
- Metagenomic analysis with Oxford Nanopore Technology (ONT)
- Established Bioinformatics Pipeline
Kindly note that this trial has reached the required number of participating centers.
For general questions, please contact:
Principal investigator: Prof. Albrecht Neesse
albrecht.neesse@med.uni-goettingen.de
Study coordinator: Dr. Christoph Ammer-Herrmenau
christoph.herrmenau@med.uni-goettingen.de